Nonsurgical Closure of Esophago–Respiratory FistulasRole for the Somatostatin Analogue Octreotide Acetate?
作者:
ERIC NYLEN,
JAMES HALL,
STEVEN KRASNOW,
KENNETH BECKER,
ROBERT WADLEIGH,
期刊:
The American Journal of the Medical Sciences
(OVID Available online 1994)
卷期:
Volume 308,
issue 3
页码: 152-156
ISSN:0002-9629
年代: 1994
出版商: OVID
关键词: Esophago–respiratory fistula;Octreotide;Esophageal cancer
数据来源: OVID
摘要:
Esophago–respiratory fistulas (ERF) do not close spontaneously and are uniformly fatal. A somatostatin analogue (octreotide acetate) was used in three consecutive patients to promote the closure of ERF. In 2 patients with esophageal cancer, treatment with octreotide acetate was associated with fistula closure in 30 and 46 days, respectively. In a third patient with virally-induced ERF, treatment was associated with improvement of the inflammation of the fistula before the patient's death from pulmonary aspiration after 40 days of treatment. These preliminary observations suggest that octreotide acetate treatment of ERF should receive further investigative scrutiny.
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