Procoagulant Activity of Mononuclear Cells Is Increased in Myeloproliferative and Myelodysplastic Diseases
作者:
M. Bazzan,
A. Vaccarino,
S. Stella,
C. Foli,
P. Omedè,
G. Gallone,
G. Tamponi,
A. Pileri,
期刊:
Pathophysiology of Haemostasis and Thrombosis
(Karger Available online 1996)
卷期:
Volume 26,
issue 3
页码: 157-163
ISSN:1424-8832
年代: 1996
DOI:10.1159/000217201
出版商: S. Karger AG
关键词: Procoagulant activity;Monocytes;Myeloproliferative diseases
数据来源: Karger
摘要:
Procoagulant activity (PCA) of peripheral mononuclear cells (PMC) was evaluated in patients with primary thrombocythemia (PT, group A), polycythemia vera (PV), idiopathic myelofibrosis (IM) and myelodysplastic syndromes (group B), and in 15 healthy subjects as control group. PCA of PMC was assayed under basal conditions and after agonist-induced stimulation: bacterial lipopolysaccharide, glycosylated granu-locyte-macrophage colony-stimulating factor, recombinant α-interferon. PCA was similar in the control group and group A when no stimulation was used, while PCA was found significantly higher in group B patients in the same conditions. In group A patients and in the control group, but not in group B patients, a lower PCA expression was found when PMC were simultaneously coincubated with LPS and α-interferon with respect to LPS incubation alon
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