Inhibition of macromolecular synthesis by cryptophycin-52
作者:
Balanehru Subramanian,
Alexander Nakeff,
Joseph Media,
Richard Wiegand,
Frederick Valeriote,
期刊:
Anti-Cancer Drugs
(OVID Available online 2002)
卷期:
Volume 13,
issue 10
页码: 1061-1068
ISSN:0959-4973
年代: 2002
出版商: OVID
关键词: Cryptophycin-52;drug action profile;G2/M arrest;macromolecular synthesis
数据来源: OVID
摘要:
Cryptophycin (CP)-52, a synthetic analog of CP-1, possesses potent and selective antiproliferative activity against human solid tumors bothin vitroandin vivo. Based on an algorithm developed in this laboratory using HCT-116 human colon adenocarcinoma cells, CP-52 exhibited a time- and concentration-dependent antiproliferative effect in thein vitroclonogenic assay. Inhibition of both DNA and RNA synthesis was observed in the absence of any effect on protein synthesis following a 24-h exposure to CP-52, at a time when proliferating cells were arrested in the G2/M phase of the cell cycle. In summary, we interpret these data to indicate that the selective inhibition of DNA synthesis may be a major causative factor responsible for the antiproliferative activity of CP-52 and subsequent G2/M arrest.
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