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Lupus Nephropathy and Pregnancy

 

作者: E. Imbasciati,   M. Surian,   S. Bottino,   P. Cosci,   G. Colussi,   G.C. Ambroso,   E. Massa,   L. Minetti,   G. Pardi,   C. Ponticelli,  

 

期刊: Nephron  (Karger Available online 1984)
卷期: Volume 36, issue 1  

页码: 46-51

 

ISSN:1660-8151

 

年代: 1984

 

DOI:10.1159/000183114

 

出版商: S. Karger AG

 

关键词: Systemic Lupus Erythematosus;Lupus nephritis;Complications of pregnancy

 

数据来源: Karger

 

摘要:

We describe 26 pregnancies in 19 patients with lupus nephritis. There were 4 spontaneous abortions, 2 therapeutic abortions, 4 stillbirths and 1 neonatal death. 10 deliverieswere preterm and 2 fetuses were small for gestational age. 8 pregnancies were not accompanied by change of renal symptoms. Mild signs of renal involvement appeared during pregnancy in 4 patients. 6 patients showed an increase in proteinuria already present before pregnancy without renal function deterioration. A moderate worsening of renal function was observed in 3 patients. 4 patients, 3 of whom had an apparent onset of systemic lupus erythematosus during pregnancy, developed anuric acute renal failure after delivery or after late spontaneous abortion. 2 of them died from sepsis and disseminated intravascular coagulation while 2 had complete recovery of renal function. A high rate of complications was observed in patients not adequately treated during pregnancy. Renal biopsy before gestation was not predictive of the outcome of nephropathy during pregnancy, and change of histology in repeated biopsies was frequently observed.

 

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