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31P NMR and HPLC Investigations of the Cyclophosphamide Metabolite, Phosphoramide Mustard

 

作者: R.W. Hardy,   P.E. Fraser,   C.M. Deber,   SJ. Soldin,  

 

期刊: Analytical Letters  （Taylor Available online 1987）
卷期: Volume 20, issue 8  

页码: 1303-1314

 

ISSN:0003-2719

 

年代: 1987

 

DOI:10.1080/00032718708064610

 

出版商: Taylor & Francis Group

 

关键词: phosphoramide mustard;HPLC;31P NMR

 

数据来源: Taylor

 

摘要:

Phosphoramide mustard (PM), a key active metabolite of the widely used anticancer drug cyclophosphamide (CP), can exist in several closely-related ionized, cyclized and substituted forms. We have developed a high pressure liquid chromatographic (HPLC) method for analysing serum concentrations of PM in order to relate these serum concentrations to toxicity and efficacy of treatment of CP.31p NMR spectroscopy is used to verify the HPLC peak homology of the proposed PM peak.

 

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