New ideas about therapy for children with developmental disabilities are constantly appearing. Frequently, the enthusiasm for these innovations is greater than the care that is taken to evaluate whether they are actually as effective as they seem at the outset and whether they do more good than harm. The present communication addresses these issues as they arise from the case report about CranioSacral Therapy for gastroesophageal reflux in an infant. We argue that the clinical research methodologies exist by which this and other novel treatments can be studied. In particular, we believe that there is an important opportunity for clinicians and researchers across North America to pool our resources and energies in a collaborative effort to move the field forward.