Serum Tumor Necrosis Factor Activity in Inflammatory Bowel Disease
作者:
MaedaM.,
WatanabeN.,
NedaH.,
YamauchiN.,
OkamotoT.,
SasakiH.,
TsujiY.,
AkiyamaS.,
TsujiN.,
NiitsuY.,
期刊:
Immunopharmacology and Immunotoxicology
(Taylor Available online 1992)
卷期:
Volume 14,
issue 3
页码: 451-461
ISSN:0892-3973
年代: 1992
DOI:10.3109/08923979209005404
出版商: Taylor&Francis
数据来源: Taylor
摘要:
AbstractSerum tumor necrosis factor (TNF) levels in 33 patients with inflammatory bowel disease (IBD) were measured by using a sensitive enzyme immunoassay. Four of five Crohn's diseases (CD) and nine of twenty eight ulcerative colitis (UC) had elevated levels of serum TNF. In active CD or UC, a greater fraction of patients studied had significantly increased serum TNF levels (3/3 for CD and 8/11 for UC). Production of TNF by peripheral blood monocytes when stimulated by lipopolysaccharide was also increased in these patients and correlated with their serum TNF levels. These rusults suggest that TNF may have some pathoetiological meaning in IBD.
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