Photo-Onycholysis Induced by 8-Methoxypsoralen
作者:
L. Zala,
A. Omar,
A. Krebs,
期刊:
Dermatology
(Karger Available online 1977)
卷期:
Volume 154,
issue 4
页码: 203-215
ISSN:1018-8665
年代: 1977
DOI:10.1159/000251067
出版商: S. Karger AG
关键词: 8-Methoxypsoralen;Photo-onycholysis;Multinucleate cells;Ribosomes
数据来源: Karger
摘要:
Two patients, whom we had under surveillance since 1969, were found to develop photo-onycholysis from orally administered 8-methoxypsoralen and sunlight irradiation. Morphological examination of the nail bed revealed characteristics of a microtrauma. The photosensitizing effect of the drug induced the generation of numerous binucleate, tetranucleate and multinucleate epithelial cells as well as numerous binucleate and tetranucleate fibroblasts in the dermis.
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