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Bivariate Latent Variable Models for Clustered Discrete and Continuous Outcomes

 

作者: PaulJ. Catalano,   LouiseM. Ryan,  

 

期刊: Journal of the American Statistical Association  (Taylor Available online 1992)
卷期: Volume 87, issue 419  

页码: 651-658

 

ISSN:0162-1459

 

年代: 1992

 

DOI:10.1080/01621459.1992.10475264

 

出版商: Taylor & Francis Group

 

关键词: Developmental toxicity;Linear model;Litter effects;Probit model;Quasi-likelihood;Random effects

 

数据来源: Taylor

 

摘要:

We use the concept of a latent variable to derive the joint distribution of a continuous and a discrete outcome, and then extend the model to allow for clustered data. The model can be parameterized in a way that allows one to write the joint distribution as a product of a standard random effects model for the continuous variable and a correlated probit model for the discrete variable. This factorization suggests a convenient approach to parameter estimation using quasi-likelihood techniques. Our approach is motivated by the analysis of developmental toxicity experiments for which a number of discrete and continuous outcomes are measured on offspring clustered within litters. Fetal weight and malformation data illustrate the results.

 

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