Hyponatremia-associated cognitive impairment in traumatic brain injury
作者:
AtchisonJames W.,
WachendorfJudith,
HaddockDavid,
MysiwW. Jerry,
GribbleMichael,
CorriganJohn D.,
期刊:
Brain Injury
(Taylor Available online 1993)
卷期:
Volume 7,
issue 4
页码: 347-352
ISSN:0269-9052
年代: 1993
DOI:10.3109/02699059309034961
出版商: Taylor&Francis
数据来源: Taylor
摘要:
The case of a traumatic brain injury (TBI) patient with dramatic cognitive deterioration in the absence of medical aetiology other than simultaneous decline in serum sodium led to an investigation of the association between declines in sodium levels and cognitive status. In a population of 50 persons undergoing TBI rehabilitation, 12 (24%) had relative (3 mEq/L) decreases in serum sodium while five (10%) experienced absolute hyponatremia (136mEq/L).Correlation with cognitive status was significant when the absolute hyponatremia group was compared with those whose sodium levels remained above 136 mEq/L. A case-matched study of the relative hyponatremia group yielded no significant association between sodium-level decreases and cognitive status. These data support previous conclusions indicating wide variation in individual responses to changes in serum sodium. The threshold for significant effects of hyponatremia may be higher in patients with TBI than in populations studied previously.
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