Influence of Single and Repeated Doses of Oxcarbazepine on the Pharmacokinetic Profile of Felodipine
作者:
G. Zaccara,
P. Gangemi,
L. Bendoni,
G. Menge,
S. Schwabe,
G. Monza,
期刊:
Therapeutic Drug Monitoring
(OVID Available online 1993)
卷期:
Volume 15,
issue 1
页码: 39-42
ISSN:0163-4356
年代: 1993
出版商: OVID
关键词: Oxcarbazepine;Felodipine;Interaction;Healthy volunteers
数据来源: OVID
摘要:
Eight healthy male volunteers (age 25–41 years) entered an open-label, within-subject study. They were treated for 13 consecutive days with felodipine (FEL) extended-release tablets, 10 mg daily. On day 6, oxcarbazepine (OXC) 600 mg was given in the morning, and from day 7 to 13, the daily dose was increased to 450 mg b.i.d. Blood samples for measurement of FEL and its pyridine metabolite (determined by gas-chromatography) were drawn just before dosing and at 2, 4, 6, 8, 10, 12, and 24 h after dosing on days 5, 6, and 13. Steady-state pharmacokinetic parameters of FEL and its pyridine metabolite were not influenced by the single dose of OXC. Repeated coadministration of OXC significantly reduced the area under the concentration-time curve (AUC0–24) of FEL by 28% and the FEL maximum plasma concentration (Cmax) by 34%. This reduction in FEL bioavailability is much smaller than that observed after co-administration of carbamazepine (CBZ) (i.e., 94%).
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