Renal Handling of Albumin and Beta-2-Microglobulin in Neonates
作者:
Horikazu Tsukahara,
Yasushi Fujii,
Shinya Tsuchida,
Masahiro Hiraoka,
Kiyoshi Morikawa,
Shinichi Haruki,
Masakatsu Sudo,
期刊:
Nephron
(Karger Available online 1994)
卷期:
Volume 68,
issue 2
页码: 212-216
ISSN:1660-8151
年代: 1994
DOI:10.1159/000188259
出版商: S. Karger AG
关键词: Urinary β2-microglobulin;Neonates;Renal function;Urinary albumin
数据来源: Karger
摘要:
Urinary albumin and β2-microglobulin (B2M) were measured during the neonatal period. Urinary albumin decreased postnatally in term neonates, while it remained almost constant in preterm neonates. Urinary B2M showed a peak level on day 7 both in term and preterm neonates. There was some trend towards higher levels of albumin and B2M with decreasing gestation, showing that glomerular permeability increases and proximal tubular protein reabsorption decreases with increasing degrees of prematurity. In sick preterms who were depressed at birth and had respiratory failure, both parameters were elevated during the first 2 weeks, indicating the presence of glomerular and tubular damage in this period. The changes in B2M with gestation or clinical condition were more pronounced than those in albumin
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