Diabetes, Hypertension and Erythrocyte Aggregation in Acute Stroke
作者:
Nancy Beamer,
George Giraud,
Wayne Clark,
Mike Wynn,
Bruce Coull,
期刊:
Cerebrovascular Diseases
(Karger Available online 1997)
卷期:
Volume 7,
issue 3
页码: 144-149
ISSN:1015-9770
年代: 1997
DOI:10.1159/000108180
出版商: S. Karger AG
关键词: Erythrocyte aggregation;Diabetes;Hypertension;Ischemic stroke;Glycosylated hemoglobin;Fibrinogen;Hyperviscosity;Stroke mechanism
数据来源: Karger
摘要:
Elevated erythrocyte (RBC) aggregation (RBC-A) may contribute to the pathogenesis of stroke and stroke recurrence. We measured RBC-A at low shear in 55 patients with acute ischemic stroke and in 24 age-balanced controls without cerebrovascular disease or vascular risk factors. RBC-A was significantly elevated in subgroups of stroke patients who were hypertensive, diabetic, or both, compared with either stroke patients lacking these risk factors (p at least < 0.01) or healthy elderly (all p < 0.001). RBC-A was normal in stroke patients (n = 14) free of both diabetes and hypertension. In a multivariate linear regression model glycosylated hemoglobin (p < 0.0001), plasma viscosity (p < 0.006) and systolic blood pressure (p < 0.05) were each independently significant and together accounted for about 52% of the variation in RBC-A in acute stroke patients. No relationship was detected between RBC-A and infarct size or among the major subtypes of ischemic stroke. The results suggest that vigorous control of both blood glucose and blood pressure may reduce the potentially damaging effects of elevated RBC-A in the cerebral vasculature.
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