Adhesion molecules are expressed in the human retina and choroid
作者:
DuguidI. G. M.,
BoydA. W.,
MandelT. E.,
期刊:
Current Eye Research
(Taylor Available online 1992)
卷期:
Volume 11,
issue sup1
页码: 153-159
ISSN:0271-3683
年代: 1992
DOI:10.3109/02713689208999526
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Immunoperoxidase staining of samples of normal human retina and choroid was performed to demonstrate selected adhesion moleculesin vivo.Intercellular adhesion molecule-1 (ICAM-1), lymphocyte function-associated antigen-3 (LFA-3) and endothelial leucocyte adhesion molecule-1 (ELAM-1) were expressed on retinal vascular endothelium and ICAM-1 and ELAM-1 in the region of the external limiting membrane. The very late antigen-2 (VLA-2) was found around the retinal ganglion cells and in the inner and outer fibre layers. The endothelium on the choriocapillaris showed moderate staining of ICAM-1, and slight staining of LFA-3 and ELAM-1. The presence of these molecules in this distribution strongly suggests they have an important role in the pathogenesis of immunologically mediated ocular conditions.
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