Low‐Dose Propranolol Reduces Aggression and Agitation Resembling That Associated with Orbitofrontal Dysfunction in Elderly Demented Patients
作者:
William Shankle,
Kristy Nielson,
Carl Cotman,
期刊:
Alzheimer Disease and Associated Disorders
(OVID Available online 1995)
卷期:
Volume 9,
issue 4
页码: 233-237
ISSN:0893-0341
年代: 1995
出版商: OVID
关键词: Aggression;Agitation;Dementia;Alzheimer;Propranolol;β-Blockers
数据来源: OVID
摘要:
Summary Although several reports suggest that intermediate to high doses of propranolol (80–160 and 200–600 mg/day) can effectively treat aggressive behavior in dementia, significant side effects can occur at these doses. To minimize these side effects, we treated and followed-up a series of 12 demented patients, whose caregivers sought medical help for their disruptive, aggressive behavior, with low-dose propranolol monotherapy (10–80 mg/day). Assessment measures obtained at baseline and during treatment by caregiver interview included ordinal ratings of aggression severity, the Cohen-Mansfield Agitation Inventory (CMAI), and the California Behavior Questionnaire (CBQ). The aggression ratings showed that low-dose propranolol effectively reduced aggression in eight of 12 patients (67%) within 2 weeks of treatment and remained effective for the duration of follow-up (1 to 14 months). Subscales of the CMAI showed responders to have significant reductions in physical and verbal aggression/agitation and in pacing/wandering. These results suggest that low-dose propranolol should be further studied for treating aggression or agitation in demented patients.
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