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Synthesis and Antimicrobial Properties of New 4‐(Alkylidene/arylidene)‐amino‐5‐(2‐furanyl)‐2,4‐dihydro‐3H‐1,2,4‐triazole‐3‐thiones and 6‐Aryl‐3‐(2‐furanyl)‐7H‐1,2,4‐triazolo[3,4‐b][1,3,4]thiadiazines

 

作者: Nedime Ergenç,   Nuray Ulusoy,   Gültaze Çapan,   Gülten Ötük Sanis,   Muammer Kiraz,  

 

期刊: Archiv der Pharmazie  （WILEY Available online 1996）
卷期: Volume 329, issue 8‐9  

页码: 427-430

 

ISSN:0365-6233

 

年代: 1996

 

DOI:10.1002/ardp.19963290811

 

出版商: WILEY‐VCH Verlag

 

关键词: 1,2,4‐triazoles;hydrazones;7H‐1,2,4‐triazolo[3,4‐b][1,3,4]thiadiazines;geometrical isomerism;antimicrobial activity

 

数据来源: WILEY

 

摘要:

AbstractA series of 4‐(alkylidene/arylidene)amino‐5‐(2‐furanyl)‐2,4‐dihydro‐3H‐1,2,4‐triazole‐3‐thiones (2) and 6‐aryl‐3‐(2‐furanyl)‐7H‐1,2,4‐triazolo[3,4‐b][1,3,4]thiadiazines (3) were synthesized. The configuration of2gwas assigned on the basis of1H‐NMR data. Of the new derivatives tested, only2b, 2g, and4fwere found to be active againstStaphylococcus aureusand/orStaphylococcus epidermidis(MIC 125–1.95 μg/ml), whereas all exhibited varying degrees

 

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