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Pituitary Secretion of Growth Hormone in Response to Opioid Peptides and Opiates Is Mediated through Growth Hormone-Releasing Factor

 

作者: William B. Wehrenberg,   Bertr Bloch,   Nicholas Ling,  

 

期刊: Neuroendocrinology  （Karger Available online 1985）
卷期: Volume 41, issue 1  

页码: 13-16

 

ISSN:0028-3835

 

年代: 1985

 

DOI:10.1159/000124147

 

出版商: S. Karger AG

 

关键词: Morphine;β-Endorphin;Growth hormone;Growth hormone-releasing factor;Passive immunization

 

数据来源: Karger

 

摘要:

Passive immunization of rats with an antiserum raised against rat growth hormone-releasing factor (GRF) completely inhibited the growth hormone (GH) response to morphine and β-endorphin but did not alter the prolactin (PRL) response to those two stimuli. These results demonstrate that opiate and opioid peptide stimulation of pituitary GH secretion is mediated through hypothalamic GRF and presents an animal model in which the stimulated secretion of GH and PRL can be specifically dissociated

 

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