Bioavailability to rats and toxicity in mice of carbofurah residues bound to faba beans
作者:
I.Y. Mostafa,
S.M.A.D. Zayed,
M. Farghaly,
F. Mahdy,
期刊:
Journal of Environmental Science and Health, Part B
(Taylor Available online 1992)
卷期:
Volume 27,
issue 4
页码: 399-405
ISSN:0360-1234
年代: 1992
DOI:10.1080/03601239209372790
出版商: Taylor & Francis Group
关键词: Faba beans;14C‐carbofuran;Bound residues;Bioavailability;Toxicity
数据来源: Taylor
摘要:
14C‐carbofuran penetrated readily into seeds ofVicia fabaand the rate of penetration was found to be dose dependent. The percentage of bound residues was generally low and did not exceed 3% of the applied dose. When the bound residues were fed to rats 46% of the radioactivity was eliminated via CO2and urine, while tissues contained 25%. Carbofuran phenol and 3‐hydroxy carbofuran represented the main metabolites in the urine. These data indicate that bean‐bound carbofuran residues are highly bioavailable to rats. Feeding mice with bound carbofuran residues for 90 days led to inhibition of erythrocyte cholinesterase activity after 30 days (35–40%) while the plasma enzyme remained unaffected. Serum transaminases and blood urea nitrogen were significantly elevated, indicating injury to hepatic and renal structures. The results strongly suggest that the bound residues can induce adverse biological effects in mice.
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