Extracts of mosquito salivary gland inhibit tumour necrosis factor alpha release from mast cells
作者:
ELYSE Y. BISSONNETTE,
PHILIPPE A. ROSSIGNOL,
A. DEAN BEFUS,
期刊:
Parasite Immunology
(WILEY Available online 1993)
卷期:
Volume 15,
issue 1
页码: 27-33
ISSN:0141-9838
年代: 1993
DOI:10.1111/j.1365-3024.1993.tb00569.x
出版商: Blackwell Publishing Ltd
关键词: Aedes aegypti;mosquito salivary gland;TNFα;mast cells
数据来源: WILEY
摘要:
SUMMARYExtracts of salivary glands of the yellow fever mosquito Aedes aegypti inhibit tumour cell‐stimulated release of tumour necrosis factor alpha (TNFα) from rat mast cells, but do not inhibit antigen‐induced histamine secretion. This inhibitory activity for TNFα is found in salivary glands of female but not in male mosquitoes. This inhibition is not mediated by bacterial contamination (LPS), by calcitonin gene related peptide (CGRP), nerve growth factor (NGF), epidermal growth factor (EGF) or transforming growth factor β (TGFβ). The factor(s) has a molecular weight>10 kDa and is neutralized by boiling for 10 min or heating at 56°C for 30 min. The modulation of this proinflammatory mediator, TNFα, produced by mast cells in sites of blood feeding may facilitate completion of the blood meal, and as reported for certain vector‐transmitted parasites, may enhance
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