Heparin-Related Osteoporosis in Rats
作者:
M. Monreal,
L. Viñas,
L. Monreal,
S. Lavin,
E. Lafoz,
A.M. Angles,
期刊:
Pathophysiology of Haemostasis and Thrombosis
(Karger Available online 1990)
卷期:
Volume 20,
issue 4
页码: 204-207
ISSN:1424-8832
年代: 1990
DOI:10.1159/000216128
出版商: S. Karger AG
关键词: Heparin;Low-Molecular-Weight Heparin;Osteoporosis
数据来源: Karger
摘要:
In an animal model, the effect of a high dose of conventional heparin (2 IU/g s.c. twice a day) and a low-molecular-weight heparin (LMWH; Fragmin, 1 anti-Xa U/g once a day) was compared with that of placebo on the mineral bone mass in the femur of rats. After 33 days of treatment no differences were found in the weight of the femur. But heparin-treated rats exhibited a lower density (1,249 ± 0.046 g/ml as compared with that in control rats (p = 0.00007) and also in LMWH-treated rats (p = 0.001). Similarly, statistically significant differences have been found in ash contents. They were higher in control rats than in heparin-treated rats (p = 0.0002), and also slightly higher than in LMWH-treated rats (p = 0.01). Our findings suggest that LMWH may have a lower osteopenic effect than that of conventional heparin
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