Evidence for a presynaptic action of chlordimeform at the insect neuromuscular junction
作者:
Daisuke Yamamoto,
Hiroshi Washio,
Jun‐Ichi Fukami,
期刊:
Archives of Insect Biochemistry and Physiology
(WILEY Available online 1983)
卷期:
Volume 1,
issue 1
页码: 33-39
ISSN:0739-4462
年代: 1983
DOI:10.1002/arch.940010105
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: insecticide chlordimeform;neuromuscular junction;transmitter release;presynaptic spike;postsynaptic potentials;Tenebrio molitor;mealworm
数据来源: WILEY
摘要:
AbstractThe mechanism of action of chlordimeform on the mealworm nerve‐muscle preparation was studied with microelectrodes. Chlordimeform affected neither the mean amplitude nor the frequency of spontaneous miniature excitatory postsynaptic potentials. Extracellular focal recordings show that in the presence of 0.8 mM chlordimeform the presynaptic spike is almost unchanged, but the quantal content for evoked transmitter release is reduced. It is suggested that chlordimeform decreases the influx of calcium at the presynaptic terminal during the active phase of the nerve terminal action potential, thereby inhibiting evoked transmitter releas
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