PCB-ASSOCIATED ALTERATION OF HEPATIC STEROID METABOLISM IN HARBOR SEALS (Phoca vitulina)
作者:
G. M. Troisi,
C. F. Mason,
期刊:
Journal of Toxicology and Environmental Health, Part A
(Taylor Available online 2000)
卷期:
Volume 61,
issue 8
页码: 649-655
ISSN:1528-7394
年代: 2000
DOI:10.1080/00984100050195134
出版商: Informa UK Ltd
数据来源: Taylor
摘要:
Hepatic cytochrome P-450 (CYP450) isozymes are involved in xenobiotic detoxification and steroid metabolism. Seals are highly exposed to polychlorinated biphenyls (PCBs) in the environment, resulting in CYP450 induction, which may have concomitant effects on CYP450 steroid metabolism. Experiments were conducted to determine rates of steroid metabolism in harbor seal (Phoca vitulina
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