T Cell Receptor (TCR) Repertoire in Alloimmune Responses
作者:
FinnOlivera J.,
DebruyneLisa A.,
BishopD. Keith,
期刊:
International Reviews of Immunology
(Taylor Available online 1996)
卷期:
Volume 13,
issue 3
页码: 187-207
ISSN:0883-0185
年代: 1996
DOI:10.3109/08830189609061747
出版商: Taylor&Francis
关键词: T cell receptor (TCR);T cell receptor repertoire;alloantigen;allograft
数据来源: Taylor
摘要:
A large number of alloantigenic determinants could be generated by both the direct and indirect alloantigen presentation pathways. Hence, a heterogeneous population of T cells expressing a wide variety of receptors would be expected to respond to this diverse array of alloantigenic determinants. However, T cells expressing highly restricted T cell receptor (TCR) variable genes have been reported in a variety of alloimmune responses. A similar phenomenon has been observed in a wide variety of other immune responses, from those induced by superantigens, to very specific responses induced by a single peptide presented by a single MHC molecule. Given this scenario, the limited number of T cell clones which dominate an allograft rejection response, or for that matter an autoimmune response or a tumor specific response, could be therapeutically targeted by virtue of the selected TCR expression.
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