The Prevalence of Avascular Necrosis in Sickle Cell Anemia: Correlation withα-Thalassemia
作者:
BallasSamir K.,
TalackiCarol A.,
RaoVijay M.,
SteinerRobert M.,
期刊:
Hemoglobin
(Taylor Available online 1989)
卷期:
Volume 13,
issue 7-8
页码: 649-655
ISSN:0363-0269
年代: 1989
DOI:10.3109/03630268908998842
出版商: Taylor&Francis
数据来源: Taylor
摘要:
The purpose of the present study was to investigate the effect ofα-thalassemia on the prevalence of avascular necrosis in 52 adult patients with sickle cell anemia.α-Globin genotypes were determined by restriction endonuclease mapping of genomic DNA extracted from peripheral blood leukocytes. Radiographs of humeral and femoral heads were interpreted by two radiologists who were not aware of the clinical picture and the genotype of the patients in the study. We present data showing that there is a significant positive correlation betweenα-gene deletion and the prevalence and extent of avascular necrosis in our patient population.
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