Predicting Plasma Concentrations of Bupivacaine After Epidural Administration in Obstetric Analgesia
作者:
&NA;,
期刊:
Therapeutic Drug Monitoring
(OVID Available online 1989)
卷期:
Volume 11,
issue 5
页码: 567-571
ISSN:0163-4356
年代: 1989
出版商: OVID
关键词: Epidural administration;Prediction;Chinese pregnant women;Gas chromatography.
数据来源: OVID
摘要:
The elimination half-life and plasma concentrations of bupivacaine were predicted after its epidural administration in six pregnant women at term for elective Caesarean section using a repeated one-point method. There was a direct correlation between predicted concentrations and observed concentrations of bupivacaine using this simple method (r= 0.9947). The assay of bupivacaine in a 0.5-ml plasma by gas chromatography with nitrogen sensitive detection can be achieved in a short time (rapid extraction and chromatographic analysis required 20 min and 10 min, respectively) to cope with emergency. It is suggested that the repeated one-point method may be useful to obtain early prediction of kinetic parameters in patients who required prolonged epidural anesthesia with bupivacaine in order to minimize adverse effects.
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