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The metabolism of thioamides by the supernatant fraction of rat liver homogenate

 

作者: M. J. GIBSON,   W. H. HUNTER,  

 

期刊: Journal of Pharmacy and Pharmacology  （WILEY Available online 1969）
卷期: Volume 21, issue S1  

页码: 195-198

 

ISSN:0022-3573

 

年代: 1969

 

DOI:10.1111/j.2042-7158.1969.tb08374.x

 

出版商: Blackwell Publishing Ltd

 

数据来源: WILEY

 

摘要:

α‐Phenyl‐α‐(2‐pyridyl) thioacetamide (SC 15396; antigastrin) is metabolized by the supernatant fraction of rat liver homogenate to give two metabolites. The major metabolite has been identified as α‐phenyl‐α‐(2‐pyridyl)acetonitrile. Three other thioamides, analogues of SC 15396 also give the corresponding nitriles

 

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