Procedures for destruction of patulin in laboratory wastes
作者:
J.Marc Frémy,
MarcelJ. J. Castegnaro,
Elisabeth Gleizes,
Michel De Meo,
Michèle Laget,
期刊:
Food Additives & Contaminants
(Taylor Available online 1995)
卷期:
Volume 12,
issue 3
页码: 331-336
ISSN:0265-203X
年代: 1995
DOI:10.1080/02652039509374310
出版商: Taylor & Francis Group
关键词: mycotoxins;patulin;decontamination
数据来源: Taylor
摘要:
Patulin is immunosuppressive and there is limited evidence of its carcinogenicity in experimental animals. The International Agency for Research on Cancer (IARC) initiated a programme for the development of degradation techniques for the commonly investigated mycotoxins. As a part of this programme, the following techniques were tested for the degradation of patulin: treatment with ammonia, treatment with ascorbic acid, and treatment with potassium permanganate in acidic or in alkaline conditions. Patulin analysis was performed by using HPLC with UV detection. Mutagenic activity of degradation residues was tested by inSalmonella typhimuriumstrains TA 97a, TA 98, TA 100, and TA 102. Complete disappearance of patulin was not achieved after 92 h of treatment with ascorbic acid. All the other methods tested led to complete removal of the molecule. However, the technique using potassium permanganate in acidic conditions produced residues which were mutagenic without activation toSalmonella typhimuriumstrains TA 100 and TA 102, which was attributed later to Mn2+. The two other techniques gave satisfactory results and were selected for further validation studies.
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