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13C and31P NMR Studies of Phosphomycin, A Phosphonate Antibiotic

 

作者: M. Delfini,   M.E. Di Cocco,   M.R. Del Giudice,   E. Gaggelli,   G. Valensin,   D. Marini,   Maurizio Delfini,  

 

期刊: Spectroscopy Letters  （Taylor Available online 1989）
卷期: Volume 22, issue 4  

页码: 363-374

 

ISSN:0038-7010

 

年代: 1989

 

DOI:10.1080/00387018908053886

 

出版商: Taylor & Francis Group

 

关键词: 13C NMR;31P NMR;Phosphonates;Antibiotics

 

数据来源: Taylor

 

摘要:

13C and31P NMR parameters were obtained for phosphomycin in water solution. The pH dependence of chemical shifts was used to calculate the pK of the second deprotonation process (pK2= 6.4). The pH dependence of13C‒31P and13P‒31H coupling constant was pointing to a change in dihedral angles and hence in the geometry of phosphomycin during deprotonation. The pH dependences of31P spin-lattice relaxation rates and13P‒{1H} NOEs were interpreted in terms of relative weigth of the 31P-1H dipolar interaction in determining the relaxation mechanism.

 

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