Rapid intravenous low‐dose diazepam as sedation for upper gastrointestinal endoscopy
作者:
D. G. SWAIN,
D. J. ELLIS,
H. BRADBY,
期刊:
Alimentary Pharmacology&Therapeutics
(WILEY Available online 1990)
卷期:
Volume 4,
issue 1
页码: 43-48
ISSN:0269-2813
年代: 1990
DOI:10.1111/j.1365-2036.1990.tb00447.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
SUMMARYOne hundred patients for endoscopy, aged, between 18 and 74 years were randomly allocated to two equal groups. Group A received 10 mg diazepam intravenously rapidly over 2–4 s; Group B received diazepam intravenously over 1–2 min, titrated to provide a satisfactory level of sedation (mean dose 15.9 mg).Patient co‐operation during endoscopy was similar in both groups, but one patient in Group A developed respiratory depression. Tests of psychomotor function after endoscopy showed greater impairment 30 min following injection for Group B, compared with Group A (P<0.02).Total or partial amnesia for endoscopy was present in 62% of Group A, and 90% in Group B (P<0.005). However, postal follow‐up showed that endoscopy was acceptable to 96% of Group A and 98% of Group B. Delayed sedation later in the day was reported by 26% of Group A compared with 48% of
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