Effect of cyclic AMP on collagen production by corneal fibroblasts
作者:
Tsih H.Wan,
WalkenbachRonald J.,
期刊:
Current Eye Research
(Taylor Available online 1986)
卷期:
Volume 5,
issue 3
页码: 177-182
ISSN:0271-3683
年代: 1986
DOI:10.3109/02713688609020040
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Subcultured bovine corneal fibroblasts accumulated cyclic AMP intracellularly and in the culture media in response to incubation with 3-isobutyl-1-methylxanthine, isoproterenol, cholera toxin or forskolin. The duration of the intracellular cyclic AMP effect was rather short using isoproterenol (less than three hours) but cholera toxin and forskolin maintained cyclic AMP stimulations for 24 hours at greater than 3-fold and 27-fold over control, respectively. Agents which stimulated adenylate cyclase by different mechanisms or mimicked the action of cyclic AMP decreased collagen secretion by these cells. In general, the degree of inhibition of collagen production was consistent with the magnitude and duration of each drug's cyclic AMP response.
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