Intracellular Concentration and Transmembrane Fluxes of Sodium and Potassium in Erythrocytes of White Normal Male Subjects With and Without a Family History of Hypertension
作者:
Paul Lijnen,
Jean-René M'Buyamba-Kabangu,
Robert Fagard,
Dominique Groeseneken,
Jan Staessen,
Antoon Amery,
期刊:
Journal of Hypertension
(OVID Available online 1984)
卷期:
Volume 2,
issue 1
页码: 25-30
ISSN:0263-6352
年代: 1984
出版商: OVID
关键词: Erythrocytes;intracellular sodium;intracellular potassium;cotransport;rubidium-uptake;normal white subjects
数据来源: OVID
摘要:
Compared with white normal males without a family history of hypertension (n=43), red blood cells of white normal males with such a family history (n=17) had a higher (P<0.01) intracellular sodium concentration (8.07 ± 0.30 versus 7.33 ± 0.17 mmol/l cells). This could be at least partly due to their lower (P<0.001) frusemide-sensitive sodium efflux rate (250 ± 19 versus 424 ± 23 µmol/l cells/h). Also their ouabain-resistant 86Rb-uptake (0.81 ± 0.06 versus 0.97 ± 0.03 µmol/l cells/h) was lower (P<0.05). Potassium concentration in the red blood cells was similar in both groups.
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