Blood pressure variability in established L‐NAME hypertension in rats
作者:
Jocelyne Blanc,
Pascal Ponchon,
Dominique Laude,
Jean-Luc Elghozi,
Bernard Jover,
期刊:
Journal of Hypertension
(OVID Available online 1999)
卷期:
Volume 17,
issue 11
页码: 1527-1534
ISSN:0263-6352
年代: 1999
出版商: OVID
关键词: nitric oxide;Poincaré plot;sympathetic nervous system;angiotensin type 1 receptor antagonist
数据来源: OVID
摘要:
MethodsBlood pressure variability was evaluated in conscious Wistar control rats and rats with established L-NAME hypertension (20 mg/kg per 24 h, 4 weeks).ResultsFinal systolic arterial pressure was 185 ± 5 and 132 ± 4 mmHg in the Nω-nitro-L-arginine methyl ester (L-NAME)-treated and control rats, respectively. The standard deviation of systolic arterial pressure in the L-NAME group was 70% greater than in the control rats, indicating a significant increase in the overall variability. Arterial pressure in the L-NAME rats exhibited aperiodical, abrupt rises and falls and data was grossly non-stationary. Blood pressure variability was therefore evaluated using Poincaré plot analysis. The variance of the difference (delta) between two successive values of systolic arterial pressure, determined for time intervals of 0.2 to 5 s (0.2 s increment), was always significantly higher in the L-NAME group compared with untreated animals. The variance of delta systolic arterial pressure increased with the time interval and plateaued for time intervals of 2.4 and 1.4 s in hypertensive and normotensive rats, respectively. These differences vanished when the sudden events oberved in L-NAME rats were omitted in the construction of Poincaré plots. Acute administration of prazosin (1 mg/kg), but not losartan (10 mg/kg) markedly reduced the variance of delta systolic arterial pressure in hypertensive rats.ConclusionsNitric oxide participates in the control of arterial pressure variability. The sympathetic nervous system seems to be a major determinant of the increased short-term variability of arterial pressure in this model.
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