Transplacental Passage of Ketamine after Intravenous Administration
作者:
Arne Ellingson,
Kjell Haram,
Norvald Sagen And,
Einar Solheim,
期刊:
Acta Anaesthesiologica Scandinavica
(WILEY Available online 1977)
卷期:
Volume 21,
issue 1
页码: 41-44
ISSN:0001-5172
年代: 1977
DOI:10.1111/j.1399-6576.1977.tb01191.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
This study was designed to measure how fast and at what concentrations ketamine would enter the foeto‐placental circulation, when administered intravenously to 10 healthy mothers immediately before forceps delivery, which was indicated by a delayed second stage of labour. It is shown that ketamine very rapidly passes the placenta, and that ketamine levels in cord blood exceed the levels in the maternal venous blood as early as 1 min 37 s after the injection. The ketamine levels in cord blood reach a maximum in the period 1 min 37 s to 2 min 5 s after the injection. Later they show a tendency to decline. A short‐lasting, marked elevation of blood pressure was produced by the ketamine anaesthesia. Two of the newborn showed low Apgar scores at 1 min. In one of them this was probably attributable to the anaesthe
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