A CRITICAL ANALYSIS OF SERUM AND URINE INTERLEUKIN‐2 RECEPTOR ASSAYS IN RENAL ALLOGRAFT RECIPIENTS1,2
作者:
ROBERT COLVIN,
FREDERIC PREFFER,
THOMAS FULLER,
MICHAEL BROWN,
STEPHEN IP,
PATRICK KUNG,
A. COSIMI,
期刊:
Transplantation
(OVID Available online 1989)
卷期:
Volume 48,
issue 5
页码: 800-804
ISSN:0041-1337
年代: 1989
出版商: OVID
数据来源: OVID
摘要:
A component of the interleukin 2 receptor (IL-2R) is released in soluble form during T cell activation and can be detected in the blood during acute renal allograft rejection. This study evaluates the diagnostic utility of a sandwich enzyme immunoassay test for serum and urine IL-2R in renal allograft recipients. A rise in serum IL-2R during the week prior to the clinical diagnosis of rejection correlated better with rejection than did isolated serum IL-2R levels or urine values. For the diagnosis of acute rejection, a rise in serum IL-2R (sensitivity 73%, specificity 87%) was comparable in overall test performance to a rise in serum creatinine (sensitivity 70%, specificity 84%). Overall, the two tests had equivalent receiver operating characteristic curves. Because the etiology of false positives in creatinine and IL-2R assays differed (primarily cyclosporine toxicity and infection, respectively), the predictive value of the combined tests was superior to either alone.
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