Human Hepatocellular Carcinoma Sensitivity to Antitumor Drugs Assayed Using the Succinate Dehydrogenase Inhibition Test
作者:
Takashi Kanematsu,
Yoshihiko Maehara,
Takashi Matsumata,
Ken Shirabe,
Kouhei Akazawa,
Keizo Sugimachi,
期刊:
Oncology
(Karger Available online 1991)
卷期:
Volume 48,
issue 1
页码: 34-38
ISSN:0030-2414
年代: 1991
DOI:10.1159/000226891
出版商: S. Karger AG
关键词: Primary hepatocellular carcinoma;Antitumor drugs;Chemosensitivity;Succinate dehydrogenase inhibition test
数据来源: Karger
摘要:
Chemosensitivity of hepatocellular carcinoma tissues from 72 patients to 6 antitumor agents was assayed using the succinate dehydrogenase inhibition test. Sensitivity was positive in 47.2% of tissues exposed to adriamycin, 53.5% to mitomycin C, 10.3% to 5-fluorouracil, 51.5% to cisplatin and aclacinomycin A, respectively, and 52.9% to carboquone. Eight percent of the tissues were sensitive to all 6 drugs, while the resistance rate to all drugs was 36.5%. The remaining 55.5% were sensitive to only some of the drugs. When a comparison of the sensitivity to the 6 drugs was made between two different areas of tumors in 16 patients, positive or negative sensitivity was in a range of 76.9–92.9%. The hypovascular masses seen on the angiography and the histologically well differentiated tumors were resistant to adriamycin, a drug most commonly prescribed to treat patients with liver cancer. For some of these tumors, mitomycin C or carboquone may be effective. Our observation shows that the succinate dehydrogenase inhibition test is useful for determining which drugs will be effective for a particular tumo
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