Interaction between Some Common Genotoxic Agents
作者:
Lars Beckman,
Ingrid Nordenson,
期刊:
Human Heredity
(Karger Available online 1986)
卷期:
Volume 36,
issue 6
页码: 397-401
ISSN:0001-5652
年代: 1986
DOI:10.1159/000153664
出版商: S. Karger AG
关键词: Arsenic;Chromosome aberrations;Copper smelter;Lead;Selenium;Sister chromatid exchanges;Sulphur dioxide
数据来源: Karger
摘要:
The clastogenic effects of arsenic, lead and sulphur dioxide and the protective effect of selenium were studied in short-term lymphocyte cultures. The three agents selected are the major toxic substances in emissions from copper smelters. Cells from non-smoking, healthy individuals were exposed to individual agents and combinations of the four agents (sodium arsenite, lead acetate, sodium sulphite and sodium selenite) and the cells were analysed for chromosome aberrations and sister chromatide exchanges. Selenium showed an antagonistic (protective) effect against the other agents. No synergistic effects were found, and the interactions between arsenic, lead and sulphur dioxide were mainly antagonistic. These rather unexpected findings indicate that mixed exposure from copper smelters, and other mixed exposures where arsenic, lead and sulphur dioxide are involved, may cause less genetic damage than expected and that an adequate dietary supplement of selenium may reduce the genotoxic effects of these agents.
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