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The Carcinogenicity of Cyclopenta[a]phenanthrene and Chrysene Derivatives in the Sencar mouse

 

作者: TarlochanS. Bhatt,   MauriceM. Coombs,  

 

期刊: Polycyclic Aromatic Compounds  (Taylor Available online 1990)
卷期: Volume 1, issue 1-2  

页码: 51-58

 

ISSN:1040-6638

 

年代: 1990

 

DOI:10.1080/10406639008034748

 

出版商: Taylor & Francis Group

 

关键词: sencar mice;skin tumours;cyclopenta[a]phenanthrenes;chrysenes

 

数据来源: Taylor

 

摘要:

Fifteen cyclopenta[a]phenanthrenes and two chrysenes, previously tested for their ability to induce skin tumours in mice of the Theiler's Original (TO) strain, were retested in Sencar mice by the initiation/promotion regime. The five compounds found to be strong carcinogens in TO mice were approximately equally active in Sencar mice with latent periods not noticably shorter, as had been anticipated from the results of others with polycylic aromatic hydrocarbons such as benzo[a]pyrene. Ten compounds inactive in TO mice also failed to induce tumours in Sencar mice. Of the remaining two compounds, both ethyl derivatives, one was apparently more active in Sencar mice, whilst the other showed the opposite behaviour. Possible reasons for these results are tentatively discussed.

 

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