Analysis of IL-6 levels in human vitreous fluid obtained from uveitis patients, patients with proliferative intraocular disorders and eye bank eyes
作者:
de BoerJoke H.,
van HarenM. A.C.,
de VriesW. A.E.J.,
BaarsmaG. S.,
de JongP. V.T.M.,
PostemaF. J.,
RademakersA. J.J.M.,
KijlstraA.,
期刊:
Current Eye Research
(Taylor Available online 1992)
卷期:
Volume 11,
issue sup1
页码: 181-186
ISSN:0271-3683
年代: 1992
DOI:10.3109/02713689208999530
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Several studies suggest a role for IL-6 in the pathogenesis of uveitis. Earlier we have shown that aqueous humour obtained from patients with uveitis contained raised levels of IL-6. In the study described here we investigated the IL-6 levels in vitreous fluid samples obtained from 75 uveitis patients with different uveitis entities. Vitreous samples from 14 patients with proliferative intraocular disorders (PID) and 29 eye bank eyes were used as controls. All the samples were tested in the IL-6 B9 bioassay as well as in a sensitive ELISA for IL-6.Raised IL-6 levels were detected in the vitreous fluid of uveitis patients as well as patients with PID, implicating IL-6 as a common inflammatory mediator. The highest mean level of IL-6 was found in the vitreous fluid of patients with acute retinal necrosis. The mean IL-6 levels measured by the ELISA were higher compared to the levels measured by the B9 bioassay. This may be caused by the presence of B9 bioassay inhibitory factors in the vitreous fluid of these patients.
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