SummaryThirty patients with generalized Hodgkin’s disease were treated with a combination of Mustine, vinblastine and procarbazine. Prednisolone was added only for symptomatic reasons. After six courses a maintenance treatment with vinblastine alone was given for two years. In 16 out of 21 patients who had previously received no treatment or only radiotherapy, a complete remission was obtained (76%).Where monochemotherapy had already been given, the results of the combination treatment were clearly inferior. All patients with a complete remission have been free of signs of disease for periods ranging from 3 to 40 months. Although leukopenia is frequent, toxicity was not a major problem.