Multiple comparisons in over‐the‐ounter drug clinical trials with both positive and placebo controls
作者:
Ralph B. D'Agostino,
Timothy C. Heeren,
期刊:
Statistics in Medicine
(WILEY Available online 1991)
卷期:
Volume 10,
issue 1
页码: 1-6
ISSN:0277-6715
年代: 1991
DOI:10.1002/sim.4780100102
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractEvaluations of the efficacy of over‐the‐ounter drugs using ANOVA techniques often misuse multiple comparison procedures. Studies that involve both a placebo control and established drugs as positive controls are especially prone to these problems. The most common mistake involves using a procedure which does not control the experimentwise type I error rate, usually the Duncan procedure or some version of multiplettests. These procedures control comparisonwise type I error rate, but lack the important experimentwise error control.The purpose of this paper is to clarify the issues involved in performing ANOVA followed by a multiple comparison procedure for over‐the‐ounter drug studies involving both placebo and positive c
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