Due to the adverse intensity of the acoustic noise within Spacelab, which will be generated during the launch of Space Shuttle, it has been determined that mitigating measures must be implemented in order to preserve the integrity of certain data to be collected during in‐orbit amphibious life sciences experiments. Because of dynamic experimentation constraints, the preliminary design of the noise abatement system required the utilization of performance trade‐offs resulting in the development of a multicomponent system to achieve effective noise control capabilities. A double‐walled life support container fully filled with water and a specimen cadaver has been experimentally modelled in full scale. Its design is intended to merge noise control capabilities with life support, data acquisition, and dynamic requirements in order to achieve the significant noise reduction required by the project.