Comparative in vitro Activity of 8 Cephalosporins on 109 Strains ofNeisseria gonorrhoeaeand 60 Strains ofNeisseria meningitidis
作者:
A. Thabaut,
J.L. Durosoir,
P. Saliou,
期刊:
Chemotherapy
(Karger Available online 1981)
卷期:
Volume 27,
issue 1
页码: 19-24
ISSN:0009-3157
年代: 1981
DOI:10.1159/000238024
出版商: S. Karger AG
关键词: Cephalosporin;N. gonorrhoeae;N. meningitidis
数据来源: Karger
摘要:
The in vitro activity of 8 cephalosporins – cephalothin, cefamandole, cefoxitin, cefuroxime, cefotaxime, cefoperazone, moxalactam and ceftriaxone (Rocephin®) was studied on 109 strains of Neisseria gonorrhoeae and 60 strains of Neisseria meningitidis, isolated from pathological material. Determination of the MICs of these antibiotics by an agar dilution method shows that on N. gonorrhoeae ceftriaxone (geometric mean of the MICs: 0.0008 μg/ml) is the most active, followed by cefotaxime (0.001 μg/ml); cefoperazone (0.008 μg/ml) and moxalactam (0.01 μg/ml) are one-tenth as active; then come cefuroxime (0.05 μg/ml), cefamandole (0.10 μg/ml) and finally cephalothin (0.26 μg/ml) and cefoxitin (0.26 μg/ml). The least susceptibility to penicillin and, to a greater degree, the production of β-lactamase (8 strains) affect the level of susceptibility to these cephalosporins, but the MICs always remain rel
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