Regiospecificity of Placental Metabolism by Cytochromes P450 and Glutathione S-Transferase
作者:
Donna J. McRobie,
Douglas D. Glover,
Timothy S. Tracy,
期刊:
Gynecologic and Obstetric Investigation
(Karger Available online 1996)
卷期:
Volume 42,
issue 3
页码: 154-158
ISSN:0378-7346
年代: 1996
DOI:10.1159/000291934
出版商: S. Karger AG
关键词: Cytochrome P450;Placenta;Glutathione S-transferase;Ethoxyresorufin;O-Deethylation;Aromatase
数据来源: Karger
摘要:
The placenta possesses the ability to metabolize numerous xenobiotics and endogenous steroids. However, it is unknown whether regional differences in these enzymatic reactions exist in the human placenta. To this end, we undertook a study of four regions of the placenta, the chorionic plate, maternal surface, placental margin and whole tissue, to assess the activities of cytochrome P450 1A1 and 19A1 (aromatase) and glutathione S-stransferase in these fractions. No differences in either P450 1 A1 or glutathione S-transferase activities were noted among any of the placental fractions. However, with respect to P450 19A1 activity, the placental margin differed significantly from all other fractions (p < 0.05). This study demonstrates that whole tissue samples of the human placenta are adequate for placental cytochrome P450 and glutathione S-transferase metabolism studies.
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