A Haplotype-Based Haplotype Relative Risk’ Approach to Detecting Allelic Associations
作者:
Joseph D. Terwilliger,
Jurg Ott,
期刊:
Human Heredity
(Karger Available online 1992)
卷期:
Volume 42,
issue 6
页码: 337-346
ISSN:0001-5652
年代: 1992
DOI:10.1159/000154096
出版商: S. Karger AG
关键词: Linkage disequilibrium;Haplotype relative risk;Allelic association;Chi-square tests
数据来源: Karger
摘要:
A novel variation of the Haplotype Relative Risk (HRR) of Rubinstein et al. [Hum Immunol 1981;3:384] is proposed, in order to glean increased information about linkage disequilibrium or allelic associations by analyzing haplotype-based data rather than genotypic data. It is shown that statistical tests based on our design give much higher power than those based on the original HRR approach. Several additional nonparametric tests based on the same data are analyzed, and power is computed for each of them. Further, parametric likelihood methods are applied to testing linkage equilibrium, and estimating δ, the coefficient of linkage disequilibrium, from the same data
点击下载:
PDF
(1576KB)
返 回