Measurement of strain exerted on blood vessel walls by double‐quantum‐filtered2H NMR
作者:
Yehuda Sharf,
Solange Akselrod,
Gil Navon,
期刊:
Magnetic Resonance in Medicine
(WILEY Available online 1997)
卷期:
Volume 37,
issue 1
页码: 69-75
ISSN:0740-3194
年代: 1997
DOI:10.1002/mrm.1910370111
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractIn this study2H double quantum‐filtered (DQF) NMR spectros‐copy of water molecules inside the blood vessel wall was used to monitor structural changes after the application of strain. This method was applied to a variety of bovine large blood vessels, including aorta, coronary artery, carotid artery, and vena cava. Inducing strain in coronary arteries by inflating them by air or water revealed dramatic changes in the2H DQF spectral lineshapes. Uniaxial extensions of longitudinal and circumferential strips led to distinct spectral responses for the different blood vessels. While the spectral lineshapes for the coronary and the carotid arteries were very sensitive to longitudinal strain, they were not affected by circumferential stretching. For the aorta there were no changes in the line‐shape upon strain. For the vena cava a large effect of strain was found that was independent of the choice of elongation axis. The effect of elongation on the spectra was assigned to the outer layer, the adventitia, whereas spectral lineshapes that originated from inner layers, media and intima, were almost insensitive to strain. Angular dependence experiments proved the presence of macroscopic order in the strained state superimposed on a broad distribution of the local directors. Our results demonstrate the sensitivity of2H DQF NMR as a probe for dynamic processes occurring on the microscopic scale in a molecular network. Key words: blood vessels; strain; double‐quantum
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