We report a 40-year-old man with a right lung mass. Flexible bronchoscopy revealed a fleshy growth in the right upper lobe bronchus. After an endobronchial biopsy was acquired, active hemorrhage occurred from the lesion. The bleeding did not respond to saline and epinephrine instillation through the bronchoscope. Intralesional injection with diluted epinephrine solution through a transbronchial cytology needle resulted in bleeding cessation. The possible mechanisms of bleeding control include vasoconstrictive and tamponade effects. This procedure may be considered a treatment option for a patient with a bleeding endobronchial mass lesion after biopsy.