Hypolipidemic Effects of 2‐Furoic Acid inSprague‐DawleyRats
作者:
Iris H. Hall,
Oi T. Wong,
David J. Reynolds,
J. J. Chang,
期刊:
Archiv der Pharmazie
(WILEY Available online 1993)
卷期:
Volume 326,
issue 1
页码: 15-23
ISSN:0365-6233
年代: 1993
DOI:10.1002/ardp.19933260105
出版商: WILEY‐VCH Verlag
数据来源: WILEY
摘要:
Abstract2‐Furoic acid was shown to be effective in lowering both serum cholesterol and serum triglyceride levels significantly in rats with an elevation of HDL cholesterol level at 20 mg/kg/day orally. LDL receptor activity was reduced in hepatocytes, aorta foam cells, small intestinal epithelium cells and fibroblasts. HDL receptor activity was elevated in the rat hepatocytes and small intestinal cells. These activities were correlated with inhibition of acyl CoA cholesterol acyl transferase activity. Neutral cholesterol ester hydrolase activity was elevated in rat hepatocytes and human fibroblasts. Thus, 2‐furoic acid appears to interfere directly with activity of intracellular enzymes rather than affecting high affinity‐mediated lipoprotein membrane receptors.In vivotreatment with 2‐furoic acid led to reduction in the liver and small intestine ATP dependent citrate lyase, acetyl CoA synthetase, acyl CoA cholesterol acyl transferase,sn‐glycerol 3‐phosphate acyl transferase, phosphatidylate phosphohydrolase and heparin induced lipoprotein lipase activities.2‐Furoic acid reduced biliary cholesterol levels but the agent increased bile salts which are lithogenic. Acute toxicity studies in mice suggest that the agent has some hepatic toxicity effects. The LD50was relatively low at 250 mg/
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