Heat shock protein 70-2+1267 AA homozygotes have an increased risk of septic shock in adults with community-acquired pneumonia
作者:
Grant Waterer,
Lama ElBahlawan,
Michael Quasney,
Qing Zhang,
Lori Kessler,
Richard Wunderink,
期刊:
Critical Care Medicine
(OVID Available online 2003)
卷期:
Volume 31,
issue 5
页码: 1367-1372
ISSN:0090-3493
年代: 2003
出版商: OVID
关键词: heat shock protein 70;pneumonia;septic shock;gene polymorphisms
数据来源: OVID
摘要:
ObjectiveHeat shock protein (HSP)70-2 is an important immunomodulatory protein induced in response to inflammatory stimuli. We assessed whether HSP70-2+1267 genotype influenced the risk of septic shock in a prospective cohort study of community-acquired pneumonia and whether HSP70-2+1267 genotype is a better predictor of septic shock than the genotype at lymphotoxin-&agr; +250.DesignProspective cohort study.SettingA large, nonprofit, private hospital system in Memphis, TN.PatientsAdults admitted with community-acquired pneumonia between 1998 and 2001. Septic shock was defined according to consensus criteria (American College of Chest Physicians/Society of Critical Care Medicine, 1992).InterventionsBlood sampling.Measurements and Main ResultsA total of 343 subjects were enrolled; 30 had septic shock. HSP70-2+1267 and lymphotoxin-&agr; +250 genotype was determined using polymerase chain reaction and restriction enzyme digestion. HSP70-2+1267 AA genotype was the strongest predictor of septic shock (p= .0005; relative risk, 3.5). Lymphotoxin-&agr; +250 AA genotype was also associated with an increased risk of septic shock (p= .002; relative risk, 2.7). Logistic regression analysis found only age (p= .04) and HSP70-2+1267 genotype (p= .006) were predictors of septic shock. The greatest risk of septic shock was associated with carriage of the HSP70-2+1267 A/lymphotoxin-&agr; +250 A haplotype (p< .0001).ConclusionsHSP70-2+1267 genotype is a stronger predictor of septic shock in patients with community-acquired pneumonia than lymphotoxin-&agr; +250 genotype.
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