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Bioassays for Retinoic Acid-Like Substances Using Cultured Human Keratinocytes

 

作者: M. Regnier,   J. Eustache,   B. Shroot,   M. Darmon,  

 

期刊: Skin Pharmacology and Physiology  （Karger Available online 1989）
卷期: Volume 2, issue 1  

页码: 1-9

 

ISSN:1660-5527

 

年代: 1989

 

DOI:10.1159/000210795

 

出版商: S. Karger AG

 

关键词: Epidermal keratin synthesis;Cross-linked envelopes;Retinoic acid-like substances;Human keratinocytes

 

数据来源: Karger

 

摘要:

Using cultured human keratinocytes, three bioassays for retinoic acid-like substances have been developed. They are based on the ability of these substances (1) to inhibit cross-linked envelope formation, (2) to inhibit the synthesis of the Kl keratin, and (3) to stimulate the synthesis of the K19 keratin. The data, expressed as 50% inhibitory or activating concentrations were used to rank compounds according to their activity.

 

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