Cytokine Gene Expression and Autoantibody Production in Sjögren's Syndrome of MRL/lpr Mice
作者:
HayashiYoshio,
HanejiNorio,
HamanoHironori,
期刊:
Autoimmunity
(Taylor Available online 1996)
卷期:
Volume 23,
issue 4
页码: 269-277
ISSN:0891-6934
年代: 1996
DOI:10.3109/08916939608995349
出版商: Taylor&Francis
关键词: Sjögren's syndrome;Cytokine gene;Autoantibody-production;MRL/lpr mice
数据来源: Taylor
摘要:
In an attempt to elucidate the mechanism of development of organ-specific autoimmune lesions resembling human Sjogren's syndrome of MRL/lpr mice, we have analyzed local cytokine gene expressions and organ-specific autoantibody productionin vivo.We have demonstrated that a major proportion of T cells bearing CD4 and Vp8 molecules are essentially responsible for triggering the autoimmunity in the salivary glands of MRL/lpr mice. The local cytokine gene expressions including interferon(1FN)-γ, IL-12(p40) mRNAs were observed during the course of murine Sjogren's syndrome in MRLApr autoimmune strain. In particular, a high level of local expressions of IL-12 mRNA was detected earlier in the proinflammatory stage of autoimmune lesions. A significant level of local expression of MHC class-II(I-Ak) mRNA was detected before the onset of inflammatory lesions in the salivary glands, and I-Ak-positive epithelial duct cells were frequently observed in the salivary glands of MRL/lpr mice. In addition, we found the salivary gland-specific autoantibody in sera from MRL/lpr mice with early phase of autoimmune lesions by immunoblot analysis. These results suggest that cytokine gene stimulation and autoantibody production are essentially involved in the development of organ-specific autoimmune lesions in Sjogren's syndrome of MRL/lpr mice.
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